Mixed bacterial-viral lung infections in patients with cystic fibrosis

The main cause of death in patients with cystic fibrosis (CF) is infectious process the lungs, particular, chronic lung infections caused by various pathogens, most often a combination bacteria, fungi, or viruses. Data on mixed bacterial and viral-bacterial from domestic foreign sources are fragmentary sparse. dominant associations viral pathogens have not been studied properly, data their epidemiological significance lacking. aim this study was to assess prevalence substantiate need for development virological monitoring. Methods . Biomaterials respiratory tract CF (409 children 160 adults CF) examined 2006 2022 were used. carried out using bacteriological methods, molecular genetic methods (RT-PCR) MALDI-TOF mass-spectrometry. Results Microflora shown be 2/3 CF. microflora lungs dynamic community microorganisms high diversity variability. In adult patients, more common than children, but composition less diverse. We isolated about 40 species bacteria 85 our sample. NFMO prevailed, including Burkholderia cepacia complex, Pseudomonas aeruginosa, Achromobacter xylosoxidans, ruhlandii, Stenotrophomonas maltophilia, Staphylococcus aureus, Candida albicans, Aspergillus spp Real-time PCR showed presence rhinovirus RNA 10% samples obtained 12.9% fibrosis. Conclusion Our results indicate continuous monitoring CF, testing